Codeine

• Codeine

Classification:

• Analgesic

Mechanism of Action:

• A prodrug of morphine
• Conversion of codeine to morphine occurs in the liver
• Metabolism effects conversion
  • Extensive metabolizer may have adverse effects from a rapid buildup of codeine metabolites
  • Poor metabolizer may get little or no pain relief
    

Indications:

• Mild to moderate pain relief

Contraindications:

• Hypersensitivity

Adverse Effects:

• Drowsiness and constipation
• Less common are itching, nausea, vomiting, dry mouth, miosis, orthostatic hypotension, urinary retention, depression, and, paradoxically, coughing
• As with all opiates, longer-term effects can vary but can include diminished libido, apathy and memory loss

• PO

• Compendium of Pharmaceuticals and Specialties (CPS)