Name:
  • Etomidate
Other Names:
  • Amidate

Classification:
  • Sedative, Hypnotic

Mechanism of Action:

  • Creates an ultra-short acting sedative/hypnotic effect
  • A non-barbiturate hypnotic that acts at the level of the reticular-activating system to produce anesthesia. Appears to depress CNS function via GABA.
  • Like the barbiturates and Propofol, etomidate is does not induce analgesia. Etomidate induces unconsciousness within one circulation time. Recovery is rapid as a result of extensive redistribution and rapid metabolism.

Indications:
  • Induction agent for RSI

Contraindications:
  • Hypersensitivity

Precautions:
  • Marked hypotension
  • Severe Asthma
  • Severe cardiovascular disease
  • Adrenal suppression

Adverse Effects:
  • Myoclonic skeletal muscle movement
  • Apnea
  • Laryngospasm 

Dose:

  
Adult:
  • 0.1 – 0.3 mg/kg IV over 15-30 seconds
  •  
Pediatric:
  • Not indicated in patients under the age of 10
Routes:
  • IV
References:
  • Compendium of Pharmaceuticals and Specialties (CPS)

Modifié le: dimanche 16 mars 2025, 20:46