Haloperidol*

• Haloperidol

Other Names:

• Haldol

Classification:

• Antipsychotic

Mechanism of Action:

• Blocks post synaptic dopamine receptors in the brain

Indications:

• Treatment/management of acute/chronic psychosis, aggressive or agitated behavior

Contraindications:

• Parkinson’s
• CNS depression, coma
• Underlying correctable causes
• Previous history Neuroleptic Malignant Syndrome

Precautions:

• May impair mental and physical abilities
• Use with caution in patients taking anticoagulants
• Diphenhydramine should be available

Adverse Effects:

• Extra pyramidal reactions treat with Benadryl 25 – 50 mg IV/IM
• Lowers seizure threshold
• Blurred Vision
• Dry mouth
• Urinary retention
• Hypotension
• Tachycardia
• Precipitation of angina
• Rarely: neuroleptic malignant syndrome
  • High fever, muscle rigidity
  • Possible confusion, muteness
  • May see profuse sweating, drooling
  • Risk of cardiac and or respiratory arrest, seizures, renal failure
• Prolonged QT interval
  

Dose:

• 2 – 5 mg IV/IM PRN

• IV, IM

• Compendium of Pharmaceuticals and Specialties (CPS)
• Pharmacology for the Prehospital Professional 2nd Edition