Name:
  • Labetalol
Other Names:
  • Trandate

Classification:
  • Beta-adrenergic receptor blocking agent

Mechanism of Action:

  • Beta I receptor blockade resulting in negative chronotropic, inotropic, and dromotropic response. End result is a decrease in myocardial oxygen consumption and work load.

Indications:
  • SVT
  • AMI
  • Unstable angina

Contraindications:
  • Severe heart failure and/or CHF
  • History of bronchospastic airway disease
  • Concurrent use of beta blockers or calcium channel blockers
  • 2nd and 3rd degree block
  • Bradycardia

Precautions:
  • Monitor EKG
  • Monitor BP
  • Monitor pulse oximetry
  • With heart failure controlled by digoxin and diuretics, use with extreme caution
  • Use cautiously in renal or hepatic failure
  • Use cautiously in elderly
  • Avoid use in patients with bronchospastic airway disease, may precipitate attack
  • Use with caution in diabetes, may mask signs and symptoms of hypoglycemia

Adverse Effects:
  • Bradycardia
  • Hypotension
  • Heart failure
  • SOB
  • Respiratory distress with laryngospasm

Dose:
  • 10 mg IV over 1 - 2 min q 10 min to a max of 150 mg or give initial dose and start an infusion at 2 - 8 mg/min
Routes:
  • IV
References:
  • Compendium of Pharmaceuticals and Specialties (CPS)
  • Pharmacology for the Prehospital Professional 2nd Edition  

Last modified: Wednesday, 26 March 2025, 1:41 PM