Labetalol

• Labetalol

• Trandate

Classification:

• Beta-adrenergic receptor blocking agent

Mechanism of Action:

• Beta I receptor blockade resulting in negative chronotropic, inotropic, and dromotropic response. End result is a decrease in myocardial oxygen consumption and work load.

Indications:

• SVT
• AMI
• Unstable angina
  

Contraindications:

• Severe heart failure and/or CHF
• History of bronchospastic airway disease
• Concurrent use of beta blockers or calcium channel blockers
• 2^nd and 3^rd degree block
• Bradycardia

Precautions:

• Monitor EKG
• Monitor BP
• Monitor pulse oximetry
• With heart failure controlled by digoxin and diuretics, use with extreme caution
• Use cautiously in renal or hepatic failure
• Use cautiously in elderly
• Avoid use in patients with bronchospastic airway disease, may precipitate attack
• Use with caution in diabetes, may mask signs and symptoms of hypoglycemia

Adverse Effects:

• Bradycardia
• Hypotension
• Heart failure
• SOB
• Respiratory distress with laryngospasm

Dose:

• 10 mg IV over 1 - 2 min q 10 min to a max of 150 mg or give initial dose and start an infusion at 2 - 8 mg/min

• IV

• Compendium of Pharmaceuticals and Specialties (CPS)
• Pharmacology for the Prehospital Professional 2^nd Edition