Name:
  • Lorazepam
Other Names:
  • Ativan

Classification:
  • Benzodiazepine

Mechanism of Action:

  • Most potent of the benzodiazepines, enhances the neurotransmitter GABA at the limbic and sub cortical levels.
  • Has a shorter half-life than diazepam
  • Induces amnesia

Indications:
  • Seizures
  • Status epilepticus
  • Premedication before cardioversion
  • Acute anxiety states

Contraindications:
  • Known hypersensitivity

Precautions:
  • Should be diluted with NS or D5W prior to administration
  • Elderly patients
  • Concomitant use of CNS depressants

Adverse Effects:
  • Hypotension
  • Drowsiness
  • Headache
  • Amnesia
  • Respiratory depression
  • Blurred vision
  • Nausea and vomiting

Dose:

  

Adult:
  • 0.05 mg/kg slow IV push; total single dose is 4 mg; repeat q 10 - 15 minutes to a max of 8 mg
  • Cardioversion:    1 - 2 mg slow IV push until desired effect
  • Acute anxiety:    0.5 - 1 mg IV/SL prn

Pediatric:
  • 0.05 mg/kg max 2 mg
Routes:
  • IV/SL
References:
  • Compendium of Pharmaceuticals and Specialties (CPS)
  • Pharmacology for the Prehospital Professional 2nd Edition  

Modifié le: mercredi 26 mars 2025, 13:56