Name:
  • Pancuronium Bromide
Other Names:
  • Pavulon

Classification:
  • Neuromuscular-blocking agent (Non-depolarizing)

Mechanism of Action:

  • Skeletal muscle relaxant
  • Paralyzes skeletal muscles including respiratory muscles
  • Competitive acetylcholine antagonist on neuromuscular junctions displacing the Ach from its post-synaptic nicotinic Ach receptors and causes no spontaneous depolarization.

Indications:
  • To achieve paralysis to facilitate endotracheal intubation

Contraindications:
  • Hypersensitivity

Precautions:
  • Paralysis occurs within 3 – 5 mins, lasts for approximately 60 mins

Adverse Effects:
  • Prolonged paralysis
  • Hypotension
  • Bradycardia
  •  

Dose:

  

Adult:
  • 0.04 – 0.1 mg/kg IV; repeat dose of 0.01 – 0.02 mg/kg q 20 mins

Pediatric:
  • 0.1 mg/kg
Routes:
  • IV
References:
  • Compendium of Pharmaceuticals and Specialties (CPS)
  • Pharmacology for the Prehospital Provider 2nd Edition  

Modifié le: mercredi, 26 mars 2025, 16:36