Name:
  • Phenobarbital
Other Names:
  • Luminal

Classification:
  • Anticonvulsant, Barbiturate

Mechanism of Action:

  • Increases the action of the inhibitory neurotransmitter of GABA in the brain
  • Appears to inhibit the release of glutamate (an excitatory neurotransmitter) from nerve endings
  • Effective anticonvulsant of relatively low toxicity
  • Depresses the sensory cortex, decreases motor activity, alters cerebellar function, and causes drowsiness, sedation, and hypnosis

Indications:
  • Major motor seizures
  • Status epilepticus
  • Acute anxiety states
References:
  • Compendium of Pharmaceuticals and Specialties (CPS)
  • Pharmacology for the Prehospital Provider 2nd Edition  

Modifié le: mercredi 26 mars 2025, 16:43