Rocuronium

• Rocuronium

• Zemuron

Classification:

• Non-depolarizing neuromuscular blocking agent

Mechanism of Action:

• Prevents acetylcholine from binding to receptors at the muscle and end plate, blocking depolarization

Indications:

• Maintains paralysis post intubation after RSI
• Maintain patient and crew safety in a combative patient, after patient intubation
• To ease ventilation and/or oxygenation of intubated patients

Contraindications:

• Hypersensitivity to bromides
• Unable to ventilate the patient with BVM

Precautions:

• Use cautiously in underlying neuromuscular disease, due to risk of prolong effects
• Use cautiously in hepatic disease
• Use cautiously in obesity
• Use cautiously in bronchogenic cancer
• Use cautiously in electrolyte disturbances
• Emergency airway management equipment, and those skilled in its use, must be readily available at all times during administration.

Adverse Effects:

• Bronchospasm, hypotension, tachycardia, dysrhythmias, N/V 

Dose:

Adult:

• 0.6 - 1.2 mg/kg IV, repeat q 30 min at 0.1 - 0.2 mg/kg prn

Pediatric:

• 0.6 - 1.2mg/kg IV, repeat q 30 min at 0.1 - 0.2 mg/kg prn effect may prolong with peds

• IV

• Compendium of Pharmaceuticals and Specialties (CPS)
• Pharmacology for the Prehospital Provider 2nd Edition