Sotalol

• Sotalol

• Betapace; Sorine

Classification:

• Beta-adrenergic receptor blocking agent

Mechanism of Action:

• Beta I receptor blockade resulting in negative chronotropic, inotropic, and dromotropic response. End result is a decrease in myocardial oxygen consumption and work load.

Indications:

• SVT
• AMI
• Unstable angina

Contraindications:

• Severe heart failure and/or CHF
• History of bronchospastic airway disease
• Concurrent use of beta blockers or calcium channel blockers
• 2^nd and 3^rd degree block
• Bradycardia with HR < 60

Precautions:

• Monitor EKG
• Monitor BP
• Monitor pulse oximetry
• With heart failure controlled by digoxin and diuretics, use with extreme caution
• Use cautiously in renal or hepatic failure
• Use cautiously in elderly
• Avoid use in patients with bronchospastic airway disease, may precipitate attack
• Use with caution in diabetes, may mask signs and symptoms of hypoglycemia

Adverse Effects:

• Bradycardia
• Hypotension
• Heart failure
• SOB
• Respiratory distress with laryngospasm

Dose:

• 1-1.5 mg/kg at 10 mg/min

• Compendium of Pharmaceuticals and Specialties (CPS)