Name:
  • Thiamine
Other Names:
  • Betaxin

Classification:
  • Vitamin B1

Mechanism of Action:

  • Combines with ATP to form thiamine pyrophosphate, a coenzyme required for carbohydrate and fat metabolism

Indications:
  • Coma of unknown origin, especially if alcohol may be involved
  • Delirium tremens

Contraindications:
  • None in the emergency setting

Precautions:
  • Administer prior to or just after the administration of glucose (D50W)
  • Rapid administration may cause vasodilatation and hypotension
  • A few cases of hypersensitivity to thiamine have been reported

Adverse Effects:
  • Hypotension
  • Dyspnea
  • Respiratory failure

Dose:
  • 100 mg IV/IM
Routes:
  • IV, IM
References:
  • Compendium of Pharmaceuticals and Specialties (CPS)
  • Pharmacology for the Prehospital Professional 2nd Edition

Last modified: Tuesday, 15 April 2025, 12:40 PM