Octreotide*

• Octreotide

• Sandostatin

Classification:

•  Octapeptide (mimics Somatostatin)

Mechanism of Action:

• Inhibits secretion of many hormones (gastrin, cholecystokinin, glucagon, growth hormone, insulin, secretin, pancreatic polypeptide, TSH, and vasoactive intestinal peptide)
• Reduce secretion of fluids by the intestine and pancreas
• Reduce gastrointestinal motility and inhibit contraction of the gallbladder
• Inhibit the action of certain hormones from the anterior pituitary
• Cause vasoconstriction in the blood vessels
• Reduce portal vessel pressures in bleeding varices

• Compendium of Pharmaceuticals and Specialties (CPS)
• Pharmacology for the Prehospital Provider 2nd Edition